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Description

Ligand binding studies of lactam-bridged variants with the conformation-specific ligand Selective Active-Fit 1 ( SAFit1 ) revealed a 6-10-fold increase in binding affinity for the L1 and L2 variants, and a 39-fold improvement for the L3 analog, confirming the successful stabilization of the transient binding pocket

Boxall Dr Gobac Dr

Biometals 27, 591599

The precipitation pH (pHp) is the pH below which an acid (or above which a base) will begin to precipitate (with all the necessary caveats associated with stochastic homogeneous and/or heterogeneous precipitation from supersaturation)